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In what the FDA said was the largest coordinated enforcement effort in agency history, the FDA issued more than 1,300 warning letters and fines to retailers who it said were illegally selling Juuls and other e-cigarettes to minors

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however, in the 1960s, chemists working at the tobacco company Philip Morris discovered that if tobacco is treated with an alkaline solution (e.g., ammonia-based), nicotine is converted to a much more volatile free base (more than 100 times), which greatly increases its absorption in the lungs and brain